Psychosis in “Cognitively Asymptomatic” Elderly Subjects is Associated With Neuritic Plaque Load, Not Neurofibrillary Tangles
نویسندگان
چکیده
منابع مشابه
Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease.
BACKGROUND The relationship between neuropathological lesions and mild, "preclinical," cognitive impairments of Alzheimer disease is poorly understood. Identification of the lesions that are most closely associated with the earliest symptoms of Alzheimer disease is crucial to the understanding of the disease process and the development of treatment strategies to affect its progression. DESIGN...
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Fractions enriched in neurofibrillary tangles (NFT) and amyloid fibrils were isolated from the cerebral cortex of three cases of senile dementia of the Alzheimer type. Distilled water suspensions of these fractions were excluded from all pore size gels and resisted digestion with various proteolytic enzymes. Formic acid/chloroform treatment of each fraction resulted in the appearance of 4,000-6...
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ژورنال
عنوان ژورنال: Alzheimer Disease & Associated Disorders
سال: 2018
ISSN: 0893-0341
DOI: 10.1097/wad.0000000000000250